GW 284543 hydrochloride( —— )

Catalog No. M20933 CAS No. 179246-08-3

GW 284543 hydrochloride is a selective inhibitor of MEK5 .

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

GW 284543 hydrochloride
Note

Research use only, not for human use.
Brief Description

GW 284543 hydrochloride is a selective inhibitor of MEK5 .
Description

GW 284543 hydrochloride is a selective inhibitor of MEK5 .
In Vitro

GW284543 (10 and 20 μM; 6 h) treatment inhibits MEK5 in a dose-dependent manner and reduces pERK5. Western Blot Analysis Cell Line:MIA PaCa-2 cells Concentration:10 and 20 μM Incubation Time:6 hours Result:Reduced phosphorylation of ERK5, and decreased endogenous MYC protein.
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK5
Research Area

——
Indication

——

Chemical Information

CAS Number

179246-08-3
Formula Weight

408.87
Molecular Formula

C23H21ClN2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

COc1cc2nccc(Nc3cccc(Oc4ccccc4)c3)c2cc1OC.Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Vaseva AV Blake DR Gilbert TSKet al.KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism[J].Cancer Cell. 2018 Nov 12;34(5):807-822.e7.

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